Over the past 9 months or so I've either experienced or heard about issues where a sequenced .NET application runs fine on a clean App-V client but not a live production build. I recently found this again in Attachmate Reflection 2011 R2 SP1; I had a sequence that worked, but when I re-sequenced it, I got a 'CLR error: 80004005' error when trying to launch on the customer's Windows 7 x64 desktop...