Software Deployment

Yes ... can be done ...
I Assume you use SCCM or SMS to deploy the application.

Just create different Install programs for different departments with department specific MST in installation command.

Eg:
[Per-System Unattended-Dep1]

Command = Msiexec /i "InstallMyMSI.msi" TRANSFORMS="Department1.MST" /qn

[Per-System Unattended-Dep2]

Command = Msiexec /i "InstallMyMSI.msi" TRANSFORMS="Department2.MST" /qn

Make sure the Programs are added under Package Definition Header.

Create two collections for each department , advertised the specific programs to collections

Spell Err: Create different collections for different department , advertised the specific programs to collections

Sorry in my haste I forgot to clarify I am using Dell Kace K1000 unit.

I'm not a KaCE user, but most deployment toolkits let you use different transforms for different distributions. You don't have different installs so that's a good thing. The challenge you may run into is when a machine from dept A with its transform moves to dept B. You'll need to resolve that if asset transfers happen a lot,

Hey d_firlotte,

Its a very similar concept with Kace.

You'll zip up the file with both MST files.

Then just create two distributions calling different answer files targeting different labels.