Edit Adobe Digital Editions .exe
Check this post.
Even then the setup randomly changes the nss and nis registry value. It didn't help either.
Better go with setup capture and create a .msi to avoid this.
ADE 4.5 makes changes to the following registry and not the above one.
Windows Registry Editor Version 5.00
This is changing dynamically everytime the setup runs and prompts the Norton installation. So better go with msi creation instead of silent switch if you want to customize it.