We had issues deploying Zbrush 4R2 floating, so we ended up using the Scripting module with the following script.
Our Zip file contained the Zbrush.exe, Zbrush License, setup.iss file, and the zbrush lib. One issue we kept on running into was that the installer would fail when sent from Kace unless we specified a user to run the script as; in this case a domain admin. Now it works like a charm.
"c:\program files\7-zip\7z.exe" e Zbrush_W_LIC.zip