ITNinja

Both products pretty much do the same thing, however Wise is now end of life and there is only InstallShield left. There is a partnership agreement between Symantec and Flexera where they are producing an 'Admin Studio for Wise' release and allowing users of Wise with a valid support agreement to upgrade.

http://spablog.ontrex.ch/2011/10/05/symantec-announces-end-of-life-of-wise-package-studio/

Hope that helps,

Dunnpy