How do i remove software in SCCM 2007?
How do i remove unused unsoftware in sccm 2007
Community Chosen Answer
Create an uninstall Program under your Package with the relevant command lines for the uninstall.
Advertise to a collection, same as when installing software and proceed as normal.
It would be normal to ensure you have a working uninstall for a Package before deploying en masse, otherwise you may have a live package that you can't remove in the wild.