'Use Following VbScript.

On Error Resume Next

Const HKEY_LOCAL_MACHINE = &H80000002

strComputer = "."
strKeyPath = ""

Set objRegistry = GetObject("winmgmts:\\" & strComputer & "\root\default:StdRegProv")
Set filesys = CreateObject("Scripting.FileSystemObject")

'Increase size of array as per per files/foders number want to delete
Dim files(1),Folders(1)

'Assign files and folder to array
'Use Folder/file path is from user profile folder path

Files(0)="AppData\Local\Adobe\123.txt"
Files(1)="AppData\123.txt"

Folders(0)="AppData\Local\Adobe"
Folders(1)="AppData\123"

DeleteFolders(Folders)
DeleteFiles(Files)

Sub DeleteFiles(Files)
strKey="SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList"
objRegistry.EnumKey HKEY_LOCAL_MACHINE, strKey, arrSubkeys
If IsArray(arrSubkeys) Then
For Each strSubkey In arrSubkeys
strKeyPath = strKey & "\" & strSubKey
strValueName = "ProfileImagePath"
objRegistry.GetExpandedStringValue HKEY_LOCAL_MACHINE,strKeyPath,strValueName,strValue
If strValue<>"" Then
For Each file In Files
If file<>"" and filesys.FileExists(strValue & "\" & file)=True Then
filesys.DeleteFile strValue & "\" & file
End If
Next
End If
Next
End If
End Sub


Sub DeleteFolders(Folders)
strKey="SOFTWARE\Microsoft\Windows NT\CurrentVersion\ProfileList"
objRegistry.EnumKey HKEY_LOCAL_MACHINE, strKey, arrSubkeys
If IsArray(arrSubkeys) Then
For Each strSubkey In arrSubkeys
strKeyPath = strKey & "\" & strSubKey
strValueName = "ProfileImagePath"
objRegistry.GetExpandedStringValue HKEY_LOCAL_MACHINE,strKeyPath,strValueName,strValue
If strValue<>"" Then
For Each Folder In Folders
If Folder<>"" and filesys.FolderExists(strValue & "\" & Folder)=True Then
filesys.DeleteFolder strValue & "\" & Folder,True
End If
Next
End If
Next
End If
End Sub

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