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If you need to make a uninstall with installshield "IsUninst.exe" that you may find in

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Uninstall...

C:\WINNT\IsUninst.exe -fC:\yourprogram\xxxx.isu

just ad a -a and it will run silent

C:\WINNT\IsUninst.exe -fC:\yourprogram\xxxx.isu -a

more switches: here