Sometimes, when you start Microsoft Outlook randomly an error message appears:

“This application has failed to start because MSVCR80.dll was not found. Re-installing the application may fix this problem.”

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For putting an end to this error message, you reinstall Microsoft Outlook but the problem may still appear.Therefore, to overcome this error message user first needs to find out the reason behind its occurrence and reach the solution.


Reason: Generally, this issue is caused by an add-in that you installed which modified or created its own OUTLOOK.EXE.MANIFEST file in Microsoft Outlook installation catalogue.


Solutions: Clearing out the offending add-in will usually fix this bug. If not, then you will need to uninstall the application.


In Microsoft Outlook 2013 and 2010:

Click on “File” tab >> “Options” >> “Add-ins” (at left pane) >> Go to “Manage: COM Add-ins” (at right pane) and click on “Go…” button.


In Microsoft Outlook 2007:

Click on “Tools” >> "Trust Center" >> "Add-ins"


In Microsoft Outlook 2003:

Click on “Tools” >> “Options” >> Click on “Other” tab >> Add-ins. Now, locate the culprit add-in and disable it.


If the add-in is not listed, you will need to edit the registry settings.

  • Open the registry editor (Click on Start button >> Run >> type regedit in the run dialog box). In short or you can also press Windows Key + R (simultaneously) to open run dialog box.
  • Now, browse to HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Office\Outlook\Addins
  • Locate the suspected add-in in the list
  • Set the LoadBehavior to 0

Delete Outlook Manifest File

To resolve, find and delete OUTLOOK.EXE.MANIFEST file from the installation directory of current version of Microsoft Outlook. By default, in Microsoft Outlook 2007 the path to locate this file is: C:\Program Files\Microsoft Office\Office12

Windows 64-bit Version: The location would be: C:\Program Files (x86)\Microsoft Office\Office12


Repair MS Office

After deleting the OUTLOOK.EXE.MANIFEST file, repair Microsoft Office installation or start Office diagnostics by following this path:

Click on “Start” button>> “All Programs” >> “Microsoft Office” >> “Microsoft Office Tools” >> “Microsoft Office Diagnostics” >> “Run Diagnostics”

Click here for info: https://support.office.com/en-us/article/Update-repair-or-uninstall-Office-2010-Click-to-Run-products-29179478-9270-4BB9-843D-F2FEC3D56C3E


Outlook Safe Mode:

Try to open Microsoft Outlook in safe mode and check if it opens. To do so:

Press “Start” key + “R” >> type “outlook.exe /safe” in the run dialog box.

NOTE: There will be a space between “exe” and “/”

Watch this video to open Outlook in safe mode: https://www.youtube.com/watch?v=ojML6NuBQGQ&feature=youtu.be


Check Your Add-Ins

Few add-ins keep realigning the file back due to which the issue may repeat even after you reboot Microsoft Outlook. To find this add-in, remove all your add-ins and enable them one by one to find the offender. Once you have detected the respective add-in, uninstall it or check with the dealer of the add-in if there is an update for it.


Reset Navigation Pane:

At last, if the issue still appears, then please try to reset navigation of Microsoft Outlook. To do so, click on “Start” button >> click “Run” and type “outlook.exe /resetnavpane” in the run dialog box.